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Heart and blood vessel disease, cardiovascular disease, includes numerous problems, many of which are related to a process called atherosclerosis.
Atherosclerosis is a condition that develops when a substance called plaque builds up in the walls of the arteries. This buildup narrows the arteries, making it harder for blood to flow through. If a blood clot forms, it can stop the blood flow. This can cause a heart attack or stroke.

 What Cause Cardiovascular Diseases?

High blood pressure can damage the delicate lining of your blood vessels.
Diabetes can lead to many other conditions that affect your cardiovascular health. Diabetes can damage blood vessels, raise “bad” cholesterol levels, lower “good” cholesterol levels, and raise blood pressure.

Obesity, excess weight can lead to the development of several other heart disease risk factors, such as high cholesterol, high blood pressure, and diabetes.

Family History, if a close relative, has experienced a heart attack or angina, you are at a higher risk of developing heart disease.

Age is a contributing risk factor for developing heart disease. As you age, your blood vessels become less flexible and more likely to develop atherosclerosis.

Men have heart attacks earlier in life than women. However, older women are more likely than men to have fatal heart attacks, after they lose the protective effect of estrogen.