(5-HTP) is the intermediate metabolite of the essential amino acid L-tryptophan in the biosynthesis of serotonin. 5-HTP is used by the human body to make serotonin, an important substance for normal nerve and brain function. The body makes 5-HTP from tryptophan (an essential amino acid) and converts it to serotonin, an important neurotransmitter (brain chemical). 5-HTP easily crosses the blood-brain barrier and effectively increases central nervous system, synthesis of serotonin.

 Benefits

5-hydroxytryptop help raise serotonin levels in the brain, which may have a positive effect on functions and processes including sleep, mood, anxiety. 5-hydroxytryptophan has been used successfully in the prevention of chronic headaches of various types, including migraine.


Supplementation with 5-hydroxytryptophan may decrease fat and carbohydrate intake by promoting a feeling of satiety fullness. 5-HTP administration causes a significant increase in the hormone leptin. Leptin plays an important role in the regulation of appetite and other physiological processes.

Side Effects

5-HTP may cause mild gastrointestinal disturbances including nausea, heartburn, flatulence, feelings of fullness. Large doses of 5-HTP may significantly increase serum levels of serotonin, this may result in the serotonin syndrome.

Symptoms and signs of the serotonin syndrome, include confusion, agitation, diaphoresis, tachycardia, myoclonus and hyperreflexia.